Co-delivery of siRNA and etoposide to cancer cells using an MDEA esterquat based drug delivery system

Design and Construction of Ph-Sensitive Drug Delivery System Based on Metal-Organic Framework (MOF) Nanoparticles for Cancer Treatment by Drug Delivery System Containing Curcumin

Introduction: Much research has been carried out to improve drug delivery and targeted drug delivery to the body in order to minimize side effects, provide controlled delivery of the drug to the desired location and to achieve optimal therapeutic effects. Zeolitic imidazolate-8 (ZIF-8) is a subset of MOFs that are biocompatible, stable in the aquatic environment and have adjustable porosity. In...

An overview of nanoparticles and their application to drug delivery in cancer: review article

Today, nanoscience has grown and developed in various medical and therapeutic areas, including cancer treatment. On the other hand, cancer and its types have been rumored and inclusive and many people suffer from this fatal and deadly disease. Currently, existing therapeutic method, including chemotherapy, radiotherapy, and etc., along with the therapeutic effect, cause complications that are u...

targeted drug delivery to cancer stem cells by hyaluronic acid-based drug conjugates: synthesis and characterization

Application of mesoporous silica nanoparticles for drug delivery to cancer cells

Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells including: drug efflux pump and activation of anti-apoptotic pathways. Cancer chemotherapy disadvanta...

Multifunctional siRNA Delivery System for Cancer Therapy

The rationale for this study is to develop a multifunctional nanomedicine platform for siRNA targeted delivery to cancerous tumors as well as the use of MRI as a non-invasive strategy to monitor the drug therapy outcome. Therefore, we propose a novel multifunctional gene delivery vector by combining the magnetic properties of iron oxide nanoparticles and their ability to package siRNA strands i...